张真真，女，博士，副教授，中共党员。

电子邮箱：zhangzhenzhen@hpu.edu.cn 办公电话：0391-3986840

主要工作与学习经历：

1. 2018年至今，河南理工大学，医学院药学系

2. 2013年-2018年，中国海洋大学，药物化学，获博士学位

3. 2009年-2013年，青岛科技大学，制药工程，获学士学位

主要研究方向：微生物天然药物化学，重点开展特殊生境来源微生物次级代谢产物研究，采用混合培养、表观遗传、前体定向生物合成等多策略充分挖掘菌株代谢潜能并进行生合成机制研究。

科研情况：

1. 河南省面上项目，2026/01-2027/12，主持。

2. 国家自然科学基金青年项目，2023/01-2025/12，主持。

主要学术论文：

1. Zhenzhen Zhang, Miaomiao Chai, Wei Li, Zhenhui Wang^* and Xueqian He^*. Myrosurroles A-R, sulfonamide-pyrrole hybrids from Myrothecium verrucaria with acetylcholinesterase inhibitory activity, Journal of Molecular Structure, 2027, 1380, 147402.

2. Wei Li, Miaomiao Chai, Longfei Zhang, Mengting Yang, Zhenzhen Zhang^*, Zhenhui Wang^* and Xueqian He^*.Anthractones A-F, antibacterial anthraquinone lactones from the biotransformation of aloe-emodin by Fusarium citricola, Phytochemistry, 2026, 243, 114726.

3. Chuanteng Ma^#, Zhenzhen Zhang^#, Wenxue Wang^#, Falei Zhang, Aowei Xie, Kaijin Zhang, Xingtao Ren, Lu Wang, Qian Che, Tianjiao Zhu, Junfeng Zhang^*, Dehai Li^*. A methyltransferase molecular switch unlocks para-quinone methide generation and oligomerization, Chemical Science, 2025, 16, 23088-23094.

4. Miaomiao Chai, Wei Li, Bing Wang, Xiaomin Zhang, Dehai Li, Zhenzhen Zhang^*, Zhenhui Wang^* and Xueqian He^*. Precursor-Directed Biosynthesis of Phenylpyrrole Analogues in Myrothecium verrucaria, Journal of Natural Products, 2025, 88, 1208-1217.

5. Zhenzhen Zhang, Wei Li, Miaomiao Chai, Bing Wang, Xiaomin Zhang, Dehai Li, Xueqian He^* and Zhenhui Wang^*.Total Synthesis of (-) and (+)-Talaroenamine B and Diphenylene Derivatives, Journal of Natural Products, 2025, 88, 842-849.

6. Zhenhui Wang, Xueqian He, Ling Yang, Zhanlin Li, and Zhenzhen Zhang^*. Sulfarulumines A-J, Sulfa-Containing Talaroenamines with Acetylcholinesterase Inhibitory Activity from Penicillium malacosphaerulum, Journal of Molecular Structure, 2024, 1300, 137294.

7. Zhenzhen Zhang, Xueqian He, Xiaomin Zhang, Dehai Li, Guangwei Wu, Zhenzhen Liu, Chao Niu, Lanping Yang, Wenting Song, Zhanlin Li, and Zhenhui Wang*. Production of Multiple Talaroenamines from Penicillium malacosphaerulum via One-Pot/Two-Stage Precursor-Directed Biosynthesis, Journal of Natural Products, 2022, 85, 2168-2176.

8. Zhenzhen Zhang, Xueqian He, Huadong Li, Zhenzhen Liu, Chao Niu, Lanping Yang, Yangyang Zhai, Baohua Hou, Baobao Zhang, Xiaomin Zhang, Dehai Li, Jingchun Zhou, and Zhenhui Wang*. Precursor-Directed Biosynthesis of Talaroenamine Derivatives using a Yellow River Wetland-Derived Penicillium malacosphaerulum, Journal of Natural Products, 2021, 84, 2923-2928.

9. Zhenzhen Zhang, Xueqian He, Guangwei Wu, Congcong Liu, Changjun Lu, Qianqun Gu, Qian Che, Tianjiao Zhu, Guojian Zhang*, Dehai Li*. Aniline-Tetramic Acids from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum L3P3 Cultured with the HDAC Inhibitor SAHA. Journal of Natural Products, 2018, 81, 1651-1657.

10. Zhenzhen Zhang, Xueqian He, Guojian Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu, Dehai Li*. Inducing Secondary Metabolite Production by Combined Culture of Talaromyces aculeatus and Penicillium variabile. Journal of Natural Products, 2017, 80, 3167-3171.